21c Museum Hotel St. Louis

The hotel is housed in a Renaissance Revival-style former YMCA. Rooms and suites feature the brand’s signature modern style with pops of color along with an original piece of art. Bathrooms look crisp and classic with a black and white color scheme.

Start your day with coffee and a hearty breakfast at the colorful Good Press. The menu highlights local roasters and purveyors. The flavors of Idol Wolf are inspired by Spain and the tapas menu fuses local and seasonal ingredients with classic Iberian sensibilities.

Locust Street Athletic and Swim Club pays homage to the building’s roots with a large pool and extensive fitness area. Personal and group training is available along with swim lessons. Book a massage to fully unwind.

Sign up for a guided tour to explore the hotel’s art museum located on the 2nd floor, featuring a 21st-century art collection that changes every year. Wind down the day with a game of billiards in the common space. See the city’s iconic Gateway Arch National Park and don’t miss the St. Louis Aquarium.