21c Museum Hotel Louisville

Guest rooms and suites feature original artwork and views of the atrium or downtown Louisville. Spacious accommodations add separate living and dining areas, while select suites include furnished outdoor terraces or residential-style layouts designed for longer stays.

Proof on Main serves southern and Appalachian-inspired cuisine with Ohio River Valley influence in a lively dining room. The Proof on Main lounge, home to the 21c Selects Private Barrel Program, serves a bourbon or cocktail surrounded by contemporary art.

Unwind with a massage at The Spa at 21c Louisville, then spend time in the sauna or steam room. The 24-hour fitness center offers space to keep up a workout routine, while the museum galleries provide a quiet place to wander at any hour.

Explore rotating exhibitions, installations, and immersive spaces in the museum, and watch the calendar for events like Art After Dark, artist-led workshops, talks, and music. Nearby, explore the Kentucky Bourbon Trail, Muhammad Ali Center, Kentucky Performing Arts Center, and Louisville Slugger Museum.