How Amex Ventures is Supporting Generative AI Innovation
Amex Ventures
June 27, 2025
At American Express, innovation has always been fundamental to the value that we provide our customers. With a 175-year legacy, we deliver our products and experiences in a way that is consistent with our brand promise of trust, service, and security, and we’ve consistently embraced emerging technologies to evolve those products and experiences—including Generative AI (Gen AI).
We began using AI in 2010 by applying machine learning to enhance fraud detection. Since then, we have expanded our use of AI to deliver more personalized experiences to our customers and streamline time-intensive processes across the company. These uses gave us a strong foundation to build upon when Gen AI emerged.
Today, American Express is currently exploring more than 70 Gen AI use cases across our organization. From improving customer service to enhancing internal productivity, each initiative utilizes a test-and-learn approach that prioritizes responsible deployment and measurable impact.
Through Amex Ventures, we’re also investing in companies that are evolving the broader Gen AI ecosystem. Our goal is to invest in startups that are not only innovating at the frontier of AI, but doing so with a strong emphasis on trust, compliance and operational rigor.
We focus our Gen AI investments in three key areas:
- Trust & Safety: Enabling responsible, secure, and compliant AI deployment
- Enterprise Efficiency: Unlocking productivity and performance gains
- Data-Driven Experiences: Leveraging proprietary data to deliver differentiated value
Recent investments include:
- Sedric, which uses Gen AI to help organizations manage compliance by automating the review of their interactions with customers
- Galileo, which supports AI teams with tools to build more accurate and reliable Gen AI systems
- Mindtrip, a travel platform that creates dynamic, shareable itineraries using Gen AI
New Pilot Program for Gen AI Startups
In addition to investing, we’re creating new pathways for startups to engage with American Express. This year, we launched a dedicated Gen AI track within our broader startup support. This track is run in collaboration with our Technology team, and it offers select startups the opportunity to pilot their solutions with American Express —gaining practical, actionable feedback and enterprise-level exposure along the way.
What We Look for in Gen AI Startups
What do we look for when investing in companies leveraging Gen AI ? Visionary leadership, deep technical expertise and a strong commitment to responsible innovation. We seek founders who are resilient, adaptable and ready to build in a space that’s constantly evolving.
The Road Ahead
The Gen AI landscape is still taking shape, but we believe it represents one of the most transformative technology shifts of our time—on par with the advent of the internet. At Amex Ventures, we’re excited to support the companies that will help define this new era.
If you’re a Gen AI founder building something bold, we’d love to connect.
Published Date June 27, 2025
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