21c Museum Hotel Louisville

Special Offer

Complimentary 4th Night.¹
Book by 27/08/2026 for travel by 31/08/2026.

Artful cultural refuge.

Set on Main Street’s Museum Row in downtown Louisville, 21c Museum Hotel Louisville is a 24/7 contemporary art museum set in a historic bourbon and tobacco warehouse. Proof on Main, a spa, and immersive exhibitions shape a stay rooted in creativity and local flavor.

Insider Tip

Join the complimentary guided museum tour in the lobby on Fridays at 5 p.m., or enjoy a complimentary bourbon pour with Nightcap at the Museum.

Explore 21c Museum Hotel Louisville

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Where You’re Staying

Guest rooms and suites feature original artwork and views of the atrium or downtown Louisville. Spacious accommodations add separate living and dining areas, while select suites include furnished outdoor terraces or residential-style layouts designed for longer stays.

Where to Dine

Proof on Main serves southern and Appalachian-inspired cuisine with Ohio River Valley influence in a lively dining room. The Proof on Main lounge, home to the 21c Selects Private Barrel Program, serves a bourbon or cocktail surrounded by contemporary art.

Where to Relax

Unwind with a massage at The Spa at 21c Louisville, then spend time in the sauna or steam room. The 24-hour fitness center offers space to keep up a workout routine, while the museum galleries provide a quiet place to wander at any hour.

What to Do

Explore rotating exhibitions, installations, and immersive spaces in the museum, and watch the calendar for events like Art After Dark, artist-led workshops, talks, and music. Nearby, explore the Kentucky Bourbon Trail, Muhammad Ali Center, Kentucky Performing Arts Center, and Louisville Slugger Museum.

Features

Pet-Friendly

Urban

Fitness Center

Parking

Electric Vehicle Charging

Entry-level rooms that accommodate 4+ people

Connecting rooms available that accommodate 4+ people

Location of 21c Museum Hotel Louisville

700 W Main St. Louisville, Kentucky 40202 United States

Louisville International Standiford Field.

THE HOTEL COLLECTION

At 21c Museum Hotel Louisville, Platinum Card Members staying 2+ nights receive:*

For stays at 21c Museum Hotel Louisville beginning on 1/1/27, Platinum Card Members staying 2+ nights receive:*

A one-category room upgrade at check-in, when available^†
A complimentary credit valued at US$100 to use towards eligible charges, such as food and beverage, spa, or other on-property charges
A complimentary credit valued at US$100 to use towards eligible charges, such as food and beverage, spa, or other on-property charges
12pm check-in, when available
Late check-out, when available

Additional benefit: